Leveraging more than 20 years of expertise in microbial expression systems, AcuraBio is offering plasmid DNA (pDNA) manufacturing services for a wide range of research, preclinical, clinical, and diagnostic applications.
We can support your project from pre-clinical stage through to commercial manufacture with fit-for-purpose quality at the right time, from early R&D all the way to full cGMP.
We are able to commence a plasmid DNA project from a sequence to supply of drug substance or critical starting material for further processing steps.
AcuraBio can meet current and future supply demands with an upstream fermentation of up to 30L scale, with streamlined and yield-optimised downstream processing using two-step chromatography, accessed through our separations supply partner Cytiva. You can read more about AcuraBio’s partnership with Cytiva here.
Applications for our pDNA manufacturing include:
- mRNA manufacturing
- Viral vector-based advanced therapies (Adeno-Associated Virus (AAV) / Lentivirus vector manufacturing)
AcuraBio offers the following grades of pDNA:
- Research-grade plasmid
- Highly documented plasmid
- GMP-grade plasmid
|Research-grade pDNA||Highly Documented pDNA||GMP-grade pDNA|
|Production||All plasmid DNA manufacturing at AcuraBio takes place in our GMP clean room suite|
AcuraBio is leveraging the latest bioprocessing innovations through the acquisition of Cytiva’s FlexFactory workflow for plasmid DNA manufacturing, allowing for enhanced yield, and efficient and standardized processes.