Leveraging more than 20 years of expertise in microbial expression systems, AcuraBio is offering plasmid DNA (pDNA) manufacturing services for a wide range of research, preclinical, clinical, and diagnostic applications.

We can support your project from pre-clinical stage through to commercial manufacture with fit-for-purpose quality at the right time, from early R&D all the way to full cGMP.

We are able to commence a plasmid DNA project from a sequence to supply of drug substance or critical starting material for further processing steps.

AcuraBio can meet current and future supply demands with an upstream fermentation of up to 30L scale, with streamlined and yield-optimised downstream processing using two-step chromatography, accessed through our separations supply partner Cytiva. You can read more about AcuraBio’s partnership with Cytiva here.


Plasmid DNA (pDNA) structure at the microscopic level

Applications for our pDNA manufacturing include:

  • mRNA manufacturing
  • Viral vector-based advanced therapies (Adeno-Associated Virus (AAV) / Lentivirus vector manufacturing)

AcuraBio offers the following grades of pDNA:

  • Research-grade plasmid
  • Highly documented plasmid
  • GMP-grade plasmid
  Research-grade pDNA Highly Documented pDNA GMP-grade pDNA
Uses
  • In vitro R&D, transfection and preclinical
  • Studies
  • Toxicology
  • GMP vector production for Phase I to II clinical trials

  • Template for GMP mRNA
  • Phase I to III and commercial viral vector manufacturing
  • DNA vaccines
Production All plasmid DNA manufacturing at AcuraBio takes place in our GMP clean room suite
Benefits
  • Suitable for discovery / pre-clinical studies
  • Fast production timelines
  • Suitable as starting material and for plasmid production for preclinical/toxicology studies
  • Quality product, prompt timelines
  • Highest quality for clinical studies and commercial production

AcuraBio is leveraging the latest bioprocessing innovations through the acquisition of Cytiva’s FlexFactory workflow for plasmid DNA manufacturing, allowing for enhanced yield, and efficient and standardized processes.

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